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False positives undermine corona antibody tests: Experts
Published in The Saudi Gazette on 08 - 04 - 2020

SINCE coronavirus started its sweep across the globe, researchers have been racing to learn everything they can about the new virus – especially how we can become immune to it. Yet there are still many unanswered questions.
So far, researchers know that if a person catches the virus and recovers, they're likely to develop some sort of immunity – though the strength and longevity are unknown. They also know that a significant proportion of people with coronavirus display no symptoms during or after having the virus, making testing and tracking cases difficult.
Taken together, these two facts could suggest that there is a sizable number of people who have had coronavirus and are now immune to it – but experts have warned that this is currently unlikely as not enough people have been infected.
Given that governments across the world are still struggling to roll out mass testing, and that current tests for immunity are flawed, much remains unknown about immunity to coronavirus.
New antibody tests seemed like a promising way to identify those who had developed immunity, but problems with the tests mean they are not as useful as many had hoped.
Here is what we do know.
Mass immunity unlikely without vaccine
Experts told Al Arabiya English that it is unlikely there is a sizable portion of the population which has developed immunity without officials knowing.
"It is too early to tell whether some portion of the population has already developed immunity but my guess on this would be no – it has not already circulated through the population," said Christine Blackburn, the deputy director, Pandemic & Biosecurity Policy Program at Scowcroft Institute of International Affairs at Texas A&M University.
If COVID-19 had managed to infect a large population that had recovered unknowingly, it would mean that the global population was closer to achieving "herd immunity" – when the majority of a population has contracted and survived a disease and is therefore immune to spreading it a second time.
Globally, we will develop herd immunity when the coronavirus has spread through enough of the population, but there is no accepted timeline for how long that will take.
"Herd immunity occurs when more and more people get infected and go on to build up antibodies against the infectious disease. It slows down and stops the spread. But for this to happen, at least 80-90 percent of the population must develop an immunity toward it," Dr. Fernanda Bonilla, staff physician, Infectious Diseases, Cleveland Clinic Abu Dhabi told Al Arabiya English.
Antibody tests touted as solution – but may not work
Researchers also know they can test for antibodies produced by COVID-19 to tell if a person had ever had the virus before. Antibody tests have been proposed as a way to identify immune people and potentially allow them to re-enter society safely.
Bonilla said the test required a finger-prick blood sample to allow doctors to detect two different antibodies produced by the body to fight off the infection, which could determine whether they were infected and have recovered.
China and Singapore have introduced antibody tests, and Germany announced it would begin issuing immunity certificates after testing for antibodies – seen as one of the long-term solutions to safely lifting lockdowns and getting people back to work.
But there are multiple problems with antibody tests.
This week, the UK's Health Secretary Matt Hancock said that no G7 country has yet developed a test that could say with certainty whether a person who recovered from coronavirus was immune.
Last week the US Food & Drug Administration approved the first serological antibody test in the US – the Cellex test. However, the Cellex test doesn't always give accurate results.
In fact, about 4.2 percent of the time, it will inaccurately say a person has COVID-19 antibodies present in their body, said Dr. Zachary Binney, an epidemiologist and assistant professor of quantitative theory and methods.
How antibody tests work
Antibody tests have two functions. They can help establish the prevalence of a disease, or how common it is in society, and they can tell if a person is immune to a certain disease.
But if a disease has a low prevalence, like is suspected of COVID-19, it is likely that antibody tests will produce a substantial number of false positives, Binney said. False positives can be produced when the test detects a similar virus, or when it may just have produced inaccurate results.
"If you're in a relatively low-risk group, like the general population, the odds that a positive test means you're immune could be 50 percent or even lower," he said.
If a person is in a high-risk group, such as health care workers and those who have come into direct contact with the virus, their likelihood of receiving a true positive are higher.
This divides the population into two groups: a small, high-risk group who are likely to receive accurate test results, and a large, low-risk group that is more likely to receive false positives.
"It's a big deal because you have two groups of positive tests, but only one group is actually correctly identified," Binney said. "Depending on the relative sizes of the chunks, you could have more false positives than true positives."
And if there's a population that's cut loose from quarantine because it is deemed immune – but is not – this could spur a second wave of cases.
"When you're looking at issuing immunity certificates, the damage from issuing a false positive is serious, especially if you issue a lot of false positives," he said.
Binney said the tests that China is using have an even higher chance of issuing a false positive. Yesterday, the UK government's testing chief, John Newton, said none of the 3.5 million antibody tests ordered from China are fit for widespread use as the tests were only able to identify immunity in those who had been severely sick.
Antibody tests can still help determine the percentage of the population that is immune, but it is impossible to know which individuals received false positives, added Binney.
Until the development of more accurate tests, it therefore seems unlikely that testing for immunity will be the solution to containing the pandemic. -- Al Arabiya English


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