Scientists in Canada and Sweden have used laboratory-made biosynthetic corneas to restore vision to patients in a small human trial, and shown for the first time that they can help to repair damaged eye tissue, according to dpa. The scientists, whose work was published on Wednesday in the Science Translational Medicine journal, said their findings offered hope for the millions of people who go blind each year because of a worldwide shortage of corneas for donation. "This study ... is the first to show that an artificially fabricated cornea can integrate with the human eye and stimulate regeneration," said May Griffith of the Ottawa Hospital Research Institute, who led the study. "With further research, this approach could help restore sight to millions of people who are waiting for a donated human cornea for transplantation." The cornea is a tiny piece of transparent, film-like tissue that covers the surface of our eyes. Made from parallel strands of the protein collagen, it refracts light to focus images on the retina. Although the fragile film is easily destroyed by trauma or infection, replacement human corneas can be used to restore vision, although this depends on a steady supply of donors. A team led by Griffith and Per Fagerholm, an ophthalmology professor and eye surgeon at Linkoping University in Sweden, conducted the study by removing diseased tissue from the corneas of 10 patients and replacing them with biosynthetic implants designed to mimic a normal human cornea. For the process they used recombinant human collagen, a substance synthesised in the laboratory to mimic human tissue and supplied by the San Francisco biotech firm FibroGen Inc. -- SPA
