NEW YORK: More than a quarter of people in the United States who take antidepressants have never been diagnosed with any of the conditions the drugs are typically used to treat, according to a study. As a result, millions could be exposed to side effects from the medicines without proven health benefits, said Jina Pagura, a psychologist and currently a medical student at the University of Manitoba in Canada, and colleagues who worked on the study. “We cannot be sure that the risks and side effects of antidepressants are worth the benefit of taking them for people who do not meet criteria for major depression,” Pagura said in an e-mail to Reuters Health. For the study, published in the Journal of Clinical Psychology, Pagura and colleagues tapped into data from the Collaborative Psychiatric Epidemiologic Surveys, which include a nationally representative sample of more than 20,000 US adults interviewed between 2001 and 2003. Roughly one in 10 people told interviewers they had been taking antidepressants during the previous year, yet a quarter of those people had never been diagnosed with any of the conditions that doctors usually treat with the medications, such as major depression and anxiety disorder. “These individuals are likely approaching their physicians with concerns that may be related to depression, and could include symptoms like trouble sleeping, poor mood, difficulties in relationships, etc.,” Pagura said. “Although an antidepressant might help with these issues, the problems may also go away on their own with time, or might be more amenable to counseling or psychotherapy.” According to the National Institute of Mental Health, nearly 15 million people in the United States suffer from major depression, and 40 million more have anxiety disorders. __
