World number one Justine Henin admitted she was bitterly disappointed at her shock third-round exit from the German Open here Thursday at the hands of Russian Dinara Safina. Third seeded Russian Svetlana Kuznetsova also crashed out after her third round defeat to Alona Bondarenko, but the shock of the day saw Henin fall 5-7, 6-3, 6-1 - a second defeat in her last three games. Safina will now play Serena Williams in the quarterfinals after the former world number one beat Poland's Agnieszka Radwanska 6-3, 6-1 to claim her 17th straight win. Against Henin, Safina had five match points in the third set at the end of the two hours 34 minute marathon and broke Henin eight times in total as the Belgian's poor run continues this season. Holder and second seed Ana Ivanovic struggled against Austria's Sybille Bammer before emerging a 7-5, 4-6, 6-4 winner. Ivanovic next plays Hungarian 10th seed Agnes Szavay who beat France's Marion Bartoli, the eighth seed, 7-5 7-5. Earlier in the day, Kuznetsova was humbled 1-6, 6-2, 6-2 by 15th seed Bondarenko, Russian Elena Dementieva she saw off compatriot Vera Dushevina 7-5, 6-3, Victoria Azarenka of Belarus thrashed Argentina's Gisela Dulko 6-3 6-1 and Jelena Jankovic of Serbia beat Maria Kirilenko of Russia 6-2, 6-4. Federer tames Karlovic In Rome, world number one Roger Federer beat Croatia's Ivo Karlovic 7-6, 6-3 in the Rome Masters on Thursday to book a quarterfinal against Czech Radek Stepanek. Earlier, Australian Open champion Novak Djokovic edged past Russia's Igor Andreev 6-3, 3-6, 6-3 in his third round match and will face Spain's Nicolas Almagro in the last eight. The Swiss player admitted that the towering Croat's big serves were hard to handle initially. Stepanek set up a match against Federer by ending Peruvian qualifier Luis Horna's impressive run with a 6-4, 1-6, 6-3 win. Almagro reached the last eight when Chilean Fernando Gonzalez, last year's finalist, pulled out of their match with a leg injury. Top American Andy Roddick took out the last Italian with a 7-6, 6-3 victory over Simone Bolelli, a surprise finalist in Munich Open last weekend. Juan Carlos Ferrero failed to build on Wednesday's shock win over fellow Spaniard Rafael Nadal and was beaten 6-4, 6-3 by Switzerland's Stanislas Wawrinka. Wawrinka will be pitched against American eighth seed James Blake, who rallied to beat Spain's Fernando Verdasco 5-7, 7-5, 6-2. Tommy Robredo of Spain also advanced beating Nikolay Davydenko of Russia 4-6, 6-2, 7
